Arundic acid (ONO-2526) inhibits stimulated-S100B secretion in inflammatory conditions

Astrocytes respond to injury by modifying the expression profile of several proteins, including S100 calcium-binding protein B (S100B), assumed be a marker as well mediator brain injury. AA is an inhibitor S100B synthesis and plays protective role in different models injury, decreases cause extracellular S100B. However, mRNA expression, content secretion do not always occur association; such, we herein investigated effect on secretion, using approaches with three stimulating conditions for namely, low potassium medium, TNF-? (in hippocampal slices) LPS exposure astrocyte cultures). Our data indicate that directly affects indicating levels this astroglial may mediating action compound. More importantly, had no basal but inhibited stimulated (stimulated either proinflammatory molecules, or TNF-?, medium). Data from slices were exposed AA, animals received acid intracerebroventricular infusion, contribute understanding its neuroprotective effect.